Disclaimer: I've not gotten into the Twilight craze; have not read the books nor seen the films. A good chunk of the people within my circle of friends do not have good things to say of it, so this post is based on my estimation that their opinions would be comparable to mine if curiosity ever got the better of me.
That said, here's a hypothetical for the internets:
If Jason Friedberg and and Aaron Seltzer (the creators of Epic Movie, Meet the Spartans, Disaster Movie, etc.) were able to salvage one more movie out of their career and made a Twilight-based Vampire Movie... would it be better or worse than the source material?
Deep down, I feel myself leaning towards worse. Crazed tween girls probably have better taste than concussed frat boys. Probably.